Canonical Source · peer reviewed study

Safety, colonisation kinetics, transmissibility, and immune correlates of protection in healthy adults inoculated with Bordetella pertussis in England: a single-centre, open-label, phase 1, controlled human infection study

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Evidence context

How this source is used

Evidence roles describe what this source helps establish inside each Investigation. They are local to that use, not permanent labels attached to the publication itself.

Investigation

Does 'terrain theory' show that germs do not cause infectious disease?

Challenges

A 2026 peer-reviewed controlled human pertussis exposure study experimentally inoculated 51 adults, analyzed 50 and documented asymptomatic B. pertussis colonization in 20; differing baseline immunity helped explain susceptibility, supporting pathogen–host interaction rather than terrain alone.

Subject families

Skin Empiric
Skin