Safety, colonisation kinetics, transmissibility, and immune correlates of protection in healthy adults inoculated with Bordetella pertussis in England: a single-centre, open-label, phase 1, controlled human infection study
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A 2026 peer-reviewed controlled human pertussis exposure study experimentally inoculated 51 adults, analyzed 50 and documented asymptomatic B. pertussis colonization in 20; differing baseline immunity helped explain susceptibility, supporting pathogen–host interaction rather than terrain alone.