Canonical Source · peer reviewed study

Prolonged fasting reduces IGF-1/PKA to promote hematopoietic-stem-cell-based regeneration and reverse immunosuppression

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Evidence context

How this source is used

Evidence roles describe what this source helps establish inside each Investigation. They are local to that use, not permanent labels attached to the publication itself.

Investigation

Does a 72-hour fast reset or regenerate the immune system?

Challenges

No direct human study here demonstrates that a 72-hour fast replaces the immune system or meaningfully improves its general function in healthy adults.

Supports

Repeated prolonged fasting and refeeding changed blood-forming stem-cell behavior in mice. The study did not demonstrate a complete three-day immune reset in healthy people.

Subject families

Skin Empiric
Skin