Prolonged fasting reduces IGF-1/PKA to promote hematopoietic-stem-cell-based regeneration and reverse immunosuppression
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No direct human study here demonstrates that a 72-hour fast replaces the immune system or meaningfully improves its general function in healthy adults.
Supports
Repeated prolonged fasting and refeeding changed blood-forming stem-cell behavior in mice. The study did not demonstrate a complete three-day immune reset in healthy people.