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Canonical Source · systematic review
This page documents how this source is reused across Claim by Claim. A source can support, challenge, qualify or contextualize different claims; appearing here does not imply endorsement of every linked proposition.
Evidence context
Evidence roles describe what this source helps establish inside each Investigation. They are local to that use, not permanent labels attached to the publication itself.
Investigation
A 2026 meta-analysis of 46 independent ME/CFS case-control datasets (1388 patients and 1349 controls) reported selected HPA-axis and cortisol differences. ME/CFS is a distinct syndrome, not proof that general chronic stress exhausts adrenal glands or validates an adrenal-fatigue diagnosis.
Subject families