Intratumoral bicarbonate functions as an adjuvant to potentiate PD-1 blockade in hepatocellular carcinoma
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A 2026 liver-cancer study found many scan responses after locally delivered bicarbonate combined with immunotherapy; without a randomized bicarbonate-free group, their respective benefits cannot be separated.
Challenges
Human evidence concerns specialist procedures delivering bicarbonate near tumors, not drinking household baking soda as a cancer cure.