Canonical Source · peer reviewed study

Comprehensive analysis of microbial content in whole-genome sequencing samples from The Cancer Genome Atlas project

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Evidence context

How this source is used

Evidence roles describe what this source helps establish inside each Investigation. They are local to that use, not permanent labels attached to the publication itself.

Investigation

Is cancer fundamentally a fungus that antifungal treatment can cure?

Challenges

A 2025 peer-reviewed independent computational reanalysis of 5,734 TCGA whole-genome samples reported far fewer reliable microbes and identified contamination/misclassification; 4,271 reprocessed samples overlap the 2022 Cell paper's TCGA subset rather than forming an independent negative patient cohort.

Subject families

Skin Empiric
Skin